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492 Epidemiological studies have found that human GPX4 gene variants are associated with obesity and cardiovascular diseases

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The effects of Cys, GSH, and MIX on Nrf2 signaling in ethanol-treated HepG2 cells were evaluated by qRT-PCR (Figure 7eg) and Western blotting (Figure 8)

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Inhibition of these mechanisms by copper efflux results in reduced vascular wall tone, increased myocardial fragility, reduced angiogenesis and ultimately myocardial injury (Fig