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In the small intestine, antimicrobial peptides, IgA, IL-33, IL-10 and transforming growth factor- (TGF), as well as cells such as CD103+ dendritic cells and regulatory T-cells are produced to also maintain gut homeostasis while the large intestine relies on a thick continuous mucus layer to compartmentalize the microbiome [32,[140], [141], [142], [143], [144]]

Introduction Proton pump inhibitors (PPIs) are currently the most widely used acid-suppressive agents and are the first-line therapy for gastric acidrelated disorders, such as peptic ulcer disease, gastroesophageal reflux disease (GERD), and Barretts esophagus ( + , K + ATPase activity in epithelial cells to prevent gastric acid secretion (Sachs et al., 2006

Moreover, it may detoxify free radicals, and their accumulation assists organisms in lessening oxidative stress [90,91,92]

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These findings highlight the centrality of the creatine-phosphocreatine system in sustaining mitochondrial bioenergetics and overall cellular viability, particularly under conditions of high or fluctuating energy demand

Ramesh, M., Khadivi, F