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4.5 AGEs formation and RAGE signaling Under hyperglycemic conditions, like those present in diabetes, glucose and glucose metabolites undergo various non-enzymatic reactions that lead to the accumulation of toxic byproducts, including advanced glycation end-products (AGEs)

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Recent observations highlighted the critical association with intestinal flora, as confirmed by the finding that metformin decreased the relative abundance of Bacteroides fragilis while increasing Akkermansia muciniphila and Bifidobacterium bifidum

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2018;23(7):764-e786

The severe complication ischemic colitis was reported incidentally, which first led to withdrawal of alosetron in the USA