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The mechanism appears to involve Gq-PLC-PKC-mediated reduction of Smad2/3 pS465/467 downstream of autocrine TGF-1, partially through NRF2-HO-1 oxidative stress quenching that removes the ROS second signal required for maximal Smad transcriptional co-activator activity

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Murdoch, C., Muthana, M., Coffelt, S

Yes, under medical guidance, it can support energy, skin health, and hormone balance during perimenopause and menopause

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His podcast provides both scientific insights and practical advice for those curious about peptide therapies