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OConnor C, White KL, Doncescu N et al (2015) NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor

6.1 Diabetes Type I diabetes, Type II DM, and gestational diabetes are characterized by hyperglycemia, dyslipidemia, and insulin resistance, which increase oxidative stress and activate the protein kinase C (PKC) as well as the receptor for advanced product glycation (AGE) and low levels of antioxidants and GPx in diabetic patients

This causes the clouding seen in cataractous lenses, which scatters light and in turn makes vision blurry (Figure 1.1)

9 Nrf2 is usually locked in the cytoplasm, but activation by DMF/MMF allows it to translocate to the nucleus where it activates a pathway of genes involved in antioxidant responses, detoxification, and the activity of cytoprotective anti-inflammatory factors

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