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The TLR2, TLR4, TLR5 and TLR9 expressed on hepatic macrophages interact with TLR ligands released by commensal gut microbiota, and promote the secretion of proinflammatory cytokines, such as TNF and IL1

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Future multicenter double-blind, randomized, placebo-controlled trials in a large and homogeneous sample of patients should focus on higher doses and more prolonged treatment

"Androgen receptor interacts with a novel MYST protein, HBO1"