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However, challenges remain regarding variability in functionality due to inactivation methods, and the need for more robust clinical evidence to support their use in routine practice (79)

In two cases, the milk of calcium extracted from the subcutaneous collections was found to contain macrophages, IL6, IL1 and TNF- suggesting activation of macrophages

doi: 10.1016/B978-0-7020-4087-0.00059-0 190

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Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs

It demonstrates notable stability in human gastric juice and systemic activity across multiple administration routes