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Hei 1-131,143) as an optical resolution reagent, resolving to obtain a desired form of the carnitine isomer in a suitable solvent by taking advantage of a solubility difference between the isomers, and then hydrolyzing the thus-resolved isomer to thereby obtain L-carnitine only

Each condition is tested at least in 4 flasks

the resin is then washed as described in the general methods and the deprotection treatment of the Fmoc group is repeated to couple the next amino acid

Further, the process of the present invention provides advantages, such as environmental friendliness due to the use of an immobilized enzyme in the preparation of the intermediate, and applicability thereof to industrial-scale production arising from decreased production costs due to the recyclability of the enzyme

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