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When a reaction process does not require an enzyme in the final product, covalent immobilization is typically used

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Br J Clin Pharmacol 30(1):115118 Moyle G, Boffito M, Fletcher C, Higgs C, Hay PE, Song IH et al (2009) Steady-state pharmacokinetics of abacavir in plasma and intracellular carbovir triphosphate following administration of abacavir at 600 milligrams once daily and 300 milligrams twice daily in human immunodeficiency virus-infected subjects

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Wolak, M