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Statin therapy is known to potentiate the effect of antihypertensive drugs [32, 33] through vasodilation, which is due to increased nitric oxide synthase activity [34], downregulation of angiotensin II-type 1 receptors [35], and endothelin-1 production [36]

Female Balb/c mice (8 weeks, Animal Resources Centre, Perth, WA, Australia) were housed at 20 2C and maintained on a 12 h light, 12 h dark cycle (lights on at 06:00 h) with ad libitum access to standard rodent chow and water

Ann.Pharmacother

& Horrax, T

Very severe spinal muscular atrophy (SMA type 0): an expanding clinical phenotype

The amyloid hypothesis of Alzheimers disease: progress and problems on the road to therapeutics