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Email: [email protected] ORCID: Affiliation: 16 Centro de Investigacin Biomdica en Red Enfermedades Neurodegenerativas (CiberNed), National Institute of Health Carlos iii, 28031 Madrid, Spain 17 Departament de Biochemistry and Molecular Biomedicine, University of Barcelona, 08028 Barcelona, Spain 18 Institut de Qumica Terica i Computacional (IQTCUB), School of Chemistry, University of Barcelona, 08028 Barcelona, Spain These authors contributed equally to this work

In some cases, more advanced treatments such as immunosuppressants may be indicated, particularly for patients with autoimmune hepatitis

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Preclinical studies and clinical trials evaluating CD38 inhibition are ongoing in patients with either solid tumors or hematological malignancies, including MM ( 2.4 CD38 enzyme activity and therapeutic antibodies: potential influence on refractoriness A crucial question is whether the binding of therapeutic CD38 antibodies interferes with the enzymes functional activity

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Zhang, H., et al.,Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells.Toxicol Sci, 2009