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Graphical Abstract Doxorubicin (DOX)-induced chemobrain may occur because of increased tumor necrosis factor-alpha (TNF-) levels in the brain, which activates inhibitory-kappa B kinase (IKK), thus triggering the dissociation of nuclear factor kappa B (NF-B) from its inhibitor protein

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10.1038/s41580-020-00324-8 57 JooN

Short SP, Barrett CW, Stengel KR, Revetta FL, Choksi YA, Coburn LA , Lintel MK, McDonough EM, Washington MK, Wilson KT, Prokhortchouk E, Chen X, Hiebert SW, Reynolds AB, Williams CS

Pentosidine in synovial fluid in osteoarthritis and rheumatoid arthritis: Relationship with disease activity in rheumatoid arthritis

Peptides with very short half-lives typically require higher daily doses administered more frequently to maintain the target plasma concentration