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Another disease marker, MCA, was also elevated in the plasma (10.85 7.163 mol/L) at weaning but did not increase further upon transition to solid chow (Figure 5F)

Abbreviations Cu: Copper Fe: Iron NRC: National Research Council LCu: The low-Cu feeding group LCG: The control group for the low-Cu feeding period SCu: The high-Cu supplement group SCG: The control group for the high-Cu feeding period Ca: Calcium P: Phosphorus S: Sulphur K: Potassium Co: Cobalt Zn: Zinc Mn: Manganese Se: Selenium Mo: Molybdenum DEGs: Differentially expressed genes FDR: False discovery rate WGCNA: The weighted gene co-expression network analysis ME: Module eigengene ROC: The receiver operating characteristic curve qRT-PCR: Quantitative real-time polymerase chain reaction GO: Gene ontology GSEA: Gene set enrichment analysis VIP: Variable importance in projection DEMs: Significantly accumulated metabolites KEGG: The kyoto encyclopedia of genes and genomes SE: Standard error NES: Normalized enrichment score MM: Module membership GS: Gene significance AUC: The area under curve PLS-DA: The partial least squares discriminant analysis NEG: Negative ion mode POS: Positive ion mode References Zhang Q, Que M, Li W, Gao S, Tan X, Bu D

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PBN was also shown to interfere with genes encoding inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and proinflammatory cytokines (Maples et al., 2004

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