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However, in the context of chronic infection and cancer, persistent antigen exposure forces antigen-specific CD8 + T cells to enter a hyporesponsive state termed exhaustion [111]

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Fibroblast growth factor receptor 4 (FGFR4): a targetable regulator of drug resistance in colorectal cancer

however, they exhibit a variety of distinct biological characteristics

Diagnostic value of serum IGF-1 and IGFBP-3 in growth hormone deficiency: A systematic review with meta-analysis

This results in variability in performance among the devices, which might not be important for bronchodilator delivery, but which could be important for delivery of other inhaled medications