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This polypharmacological approach stands in contrast to conventional chemotherapeutics, which typically target single molecules and are therefore more susceptible to resistance development (Liao et al., 2023)

Cells were fixed by vortexing with simultaneous addition of Complete Cell Fixation Solution (Fixation Reagent1, ice-cold 100% methanol, Stanlab, Poland) with DEPC, followed by 15 min incubation on ice and then washed with WRS Buffer (Scale Biosciences) and resuspended in WRS Buffer

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He was born October 16, 1915

[PMC free article: PMC3034013] [PubMed: 21157430] 192

Exemplary cells for use in the screening methods Cells which are suitable for use in the screening methods include both cultured mammalian cells and cells which are present in an animal