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Statements Author contributions YW: Visualization, Writingoriginal draft, Writingreview and editing

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Effects of an effective concentration of nicotine (N 250 g/ml) in the presence or absence of glutathione (G 14 g/ml) on the metabolism of 14C-testosterone and 14C-4-androstenedione by HPF (Figures 5 & 6) When 14C-testosterone was used as substrate (Figure 5), the main metabolites formed were Diols, DHT and androstanedione (A), of which DHT and A are shown

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