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ACS Chem Neurosic 10 (2), 777782

Impaired ubiquitin-proteasome-mediated PGC-1 protein turnover and induced mitochondrial biogenesis secondary to complex-I deficiency

Inhibiting it with 5-Amino-1MQ slows energy/repair declines.[6][7][29] As a NAD+ drain, targeting NNMT preserves it, supporting mitochondrial health and longevity protocols