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Demonstrating that ferroptosis is a driver of disease in CF offers the opportunity to intervene therapeutically and in this study we showed that the GSH prodrug N-acetylcysteine (NAC) was able to recover the levels of GSH back to normal and alleviate erastin-induced ferroptotic cell death

& Watanabe, Y

In summary, miRNAs influence targeted therapy sensitivity by affecting signaling pathways, intracellular processes, and receptor regulation, highlighting their crucial role in tumor drug resistance and offering potential targets for new therapies

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