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Paclitaxel does not directly affect mitochondrial DNA but induces swollen and vacuolated mitochondria in both myelinated and unmyelinated sensory axons, and these changes are accompanied by increased production of reactive oxygen species in the nervous system [20, 53,54,55]

A systematic review that investigated the beneficial effects of L-Carnitine supplementation for weight management in overweight and obese adults found that L-Carnitine significantly reduced weight, BMI, and fat mass[2] 2

Schirmer Tear Tests are also used to determine tear production by measuring tear flow with strips of litmus paper over a period of five minutes

Oxidative Stress LAC promoted the removal of oxidation products and provided acetyl groups to regulate the expression of neuro-nutrients and glutamate genes (99)

The selection of L-carnitine doses was based on the previous studies (Aboubakr et al., 2020), (Rajasekar et al., 2008)

The expression of SREBP1c is decreased by the vitamin D-mediated inhibition of the Akt/mTOR signaling pathway