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In the first strategy, S-soil specificity of phylotypes was identified independently for each study that included both S-soil and NS-soil samples using three different analytical methods: LEfSe (LDA 3, p 0.05 with 1,000 bootstraps), Indicator Species Analysis (ISA, p 0.05 using 1,000 permutations via the r.g function in the indicspecies package [67]), and co-occurrence analysis using q2-SCNIC [68]

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Global sensitivity analysis revealed that k 02 (oxygen concentration) is the most sensitive parameter for OCR and ROS output, suggesting that biological environments with elevated oxygen presence could be more susceptible to redox-induced ROS