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Accordingly, PDE5-Is have gained growing attention as potential therapeutic agents for the treatment of several CNS-related diseases, such as Alzheimers disease (AD), cognitive deficits, strokes, multiple sclerosis (MS), depression, noise-induced hearing loss (NIHL) and neuropathic pain that will all be discussed in this section (Figure 4)

[DOI] [Google Scholar] 209.Pulito C., Mori F., Sacconi A., Casadei L., Ferraiuolo M., Valerio M.C., Santoro R., Goeman F., Maidecchi A., Mattoli L., et al

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Many experimental studies have shown that female mice are less susceptible to APAP hepatotoxicity than males and that the sex differences are substantial [17,18,35]

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