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Effect of physiological doses of oral vitamin B12 on plasma homocysteine: a randomized, placebo-controlled, double-blind trial in India

Sometimes, people are unaware they have vitamin B12 deficiency because they take in large amounts of folic acid through diet or supplements

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These vitamins are structurally diverse (derivatives of sugar, pyridine, purines, pyrimidine, organic acid complexes and nucleotide complex) and act as coenzymes, as oxidation-reduction agents, possibly as mitochondrial agents

Oxidative inflammation is also thought to be a major cause of molecular damage through various stressors (McGarry et al., 2018)

In other words, the physiology of B12 reserves is as follows: if we have large reserves, the body knows that it has plenty and is not very interested in safeguarding them, so it loses more