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For long-term studies, this can sometimes present practical challenges, especially if high frequency of administration is required

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Recent literature suggests that short-term patient survival and graft survival are similar in C19(+) versus C19(-) donors

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Rapamycin, an inhibitor of mammalian target of rapamycin (mTOR) complex 1, exhibits cardioprotective effects in ferroptotic cells, where mTOR overexpression protects against iron-overload-induced cell death, a process exacerbated by mTOR deficiency (67, 68)