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When areas of the body are subject to ongoing inflammation, many issues can arise

In addition to the protective effects of ASX in various chronic and acute diseases, we also summarize recent advances for the inconsistent roles of ASX in infectious diseases, and give our opinion that the exact function of ASX in response to different pathogen infection and the potential protective effects of ASX in viral infectious diseases should be important research directions in the future [78]

Iron released via HMOX1 activated the iron-dependent histone demethylase KDM6B, driving the expression of myeloid cell-associated proteins which promoted recruitment of immunosuppressive myeloid-derived suppressor cells and tumor-associated macrophages (TAMs) to the tumor site [59]

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