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Importantly, several of the ten high-confidence M-QTLs, identified based on cluster size 5, R 2 10%, and 5 nested CGs, exhibited strong convergence across multiple analytical approaches, including significant MTAs, haplotype-tagging SNPs, and PPI hub genes

Neuropsychologia 2009;47:2044-55

Cadmium is a toxic environmental pollutant known to promote tumorigenesis through mechanisms including the induction of EMT

A key framework here is Chronic Inflammatory Response Syndrome (CIRS), a condition in which the immune system enters a state of persistent activation following biotoxin exposure