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Saudi J Biol Sci 2014

The Free Radical Theory of Aging suggests just thatoxidants, radicals, and toxins debilitate cells and deprive us of our youth

4B), accumulated following both pharmacological and genetic inhibition, confirming effective blockade of DHODH activity (Fig

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Catalase-Related Diseases Catalase deficiency or malfunctioning is associated with many diseases such as diabetes mellitus, vitiligo, cardiovascular diseases, Wilson disease, hypertension, anemia, some dermatological disorders, Alzheimer's disease, bipolar disorder, and schizophrenia [2426] (Figure 5)

These results could be explained because of a defect in mitochondrial biogenesis processes, which would result in aberrant mitochondria, thus, contributing to the pathophysiology of AD, as already demonstrated in previous studies where mitochondrial biogenesis markers such as PGC-1a are reduced (Sheng et al., 2012)