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ESPGHAN score correctly diagnosed these children when additional points are given for the presence of peri-nuclear neutrophilic antibodies and cholangiographic abnormalities [29]

Depletion of environmental glutamine enhances Wnt signaling in mutant intestinal organoids, while reduced intracellular -KG levels lead to adenocarcinoma formation in vivo

In a randomized clinical trial, a 0.5 g/kg body weight daily dose of glutamine for 2 months decreased intestinal permeability and improved morphology in patients with Crohns disease (Benjamin 2011)

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This paper is an important review of the inflammatory mechanisms in tendinopathy pathogenesis