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reported that the UDP-GlcNAc pathway plays a key role in the polarization process of M2 macrophages and that glutamine is the main source of nitrogen in UDP-GlcNAc [25]

4.3 Targeting CSCs through coordinated pathway disruption SFN demonstrates remarkable efficacy against CSCs through its ability to simultaneously disrupt multiple signaling pathways that maintain stemness and self-renewal capacity

Patients with more advanced disease, characterized by sinus tracts and scarring, often require a combination of antibiotics, such as clindamycin and rifampicin [198, 199] (Fig

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H., Yong, C