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Naunyn Schmiedebergs Arch Pharmacol (2018) 391(8):84758

Altschul, Adam A

**Composition and Research Rationale** Each 80mg vial of KLOW contains: - **GHK-Cu (Copper Tripeptide-1) 50mg**: A naturally occurring copper-binding tripeptide researched for its role in collagen synthesis, wound contraction, and gene expression modulation related to tissue remodeling

These suggest that the underlying architectural instability persists but is partially masked by the mechanical constraints of the collagen-rich environment

Miyazaki T, Nakajima W, Hatano M, Shibata Y, Kuroki Y, Arisawa T, et al

Retinol is also the one most likely to challenge the skin barrier when someone uses too much, starts too fast, or stacks it with too many other strong actives