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PDA, sharing the BPC-157 sequence, is not a separately classified entity with a different regulatory status

When intestinal epithelial cells and immune cells detect bacterial components and metabolites through pattern recognition receptors (e.g., Toll-like receptors, TLRs), they activate NADPH oxidases, resulting in ROS production (O 2 - , H 2 O 2 )

Diabetic cardiomyopathy and its mechanisms: Role of oxidative stress and damage

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Consistent with this, they also identified PC in 78 kDa glucose-regulated protein (GRP78/HSPA5) and Pancreatic amylase 2, two known autoantigens in T1D (180, 181)