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The pathophysiology of MASLD includes lipid accumulation ( de novo lipogenesis), insulin resistance (IR), oxidative stress, gut microbiota, and liver inflammation [21, 22] (Fig

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J Pharmacol Exp Ther 187:195202 Kang AM, Padilla-Jones A, Fisher ES, Akakpo JY, Jaeschke H, Rumack BH, Gerkin RD, Curry SC (2020) The effect of 4-methylpyrazole on oxidative metabolism of acetaminophen in human volunteers

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