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(PubMed) Kumaran S, Panneerselvam KS, Shila S, Sivarajan K, Panneerselvam C

Existing clinical studies often suffer from single-center experiments, small sample sizes, short follow-up durations, and the absence of standardized endpoint measures, which challenge comparative analyses across studies and the establishment of conclusive evidence

This decrease in disulfide formation can be ascribed to the reduction in total PDI protein levels and in the ratio of oxidized versus reduced PDI that we observed in differentiating hypoxic mutant chondrocytes (Fig