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Mistake 4: Changing timing during dose escalation This is a critical error

Moreover, the brains neuronal membranes are rich in unsaturated fatty acids, making them susceptible to oxidative damage, which can produce reactive aldehydes (Maiorino et al., 2018)

Permeabilization was performed using 0.5% Triton X-100 (Sigma) for 5 min at room temperature

It is well known that proteasomes (complex intracellular proteases) are able to mildly degrade oxidized proteins (Dunlop et al

Given that the infectivity of SARS-CoV-2 relies on binding its S protein with the entry receptor hACE2, inhibiting this interaction is therefore a promising treatment strategy 10,11,12

The same results were shown with hepatic COX-2 protein and gene in our previous work []