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Thus the best-known "function" of B 12 (that which is involved with DNA synthesis, cell division, and anemia) is a facultative function that is mediated by B 12 -conservation of an active form of folate which is needed for efficient DNA production

The implications of NNMT inhibition extend far beyond simple cofactor availability, influencing fundamental cellular processes including mitochondrial biogenesis, oxidative stress management, and epigenetic regulation

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Dosing, in Practice Commonly observed research protocols land around 50 mg/day to start, titrating to 100 mg/day, taken orally, usually morning and fasted

Choline may increase cholinergic tone and could theoretically augment adverse reactions when combined with acetylcholinesterase inhibitors such as donepezil

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