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10.1186/s13148-023-01467-z 66

Oxidative stress induces MPT by targeting specific cysteine residues of cyclophillin D, which results in mitochondrial depolarization, oxidative phosphorylation uncoupling, release of intra-mitochondrial ions and metabolic intermediates, mitochondrial swelling and decrease in ATP synthesis

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After polymerization, the collagen droplets were overlaid with complete expansion medium supplemented with either 1 mM Mn 2+ or 5 nM scTS2/16