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The peptide utilizes a "Push-Pull" mechanism on adipose tissue

PARP1 inhibition using 3-AB has shown protective effects in various models of ischemia-reperfusion injury

AOD 9604 group showed smooth cartilage surface, increased thickness, and reduced fibrosis

Enhanced polyamine flux activation leads to elevated energy expenditure via polyamine acetylation, utilizing Acetyl-coenzyme A (acetyl-CoA) to generate acetylpolyamines (Jackson et al., 2003)