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Probiotics can reverse alterations in gut microbiota composition, restore gastrointestinal function, reduce intestinal leakage and enteric nervous system inflammation, exert antioxidant effects, improve mitochondrial function, and enhance energy metabolism in the brain and muscles, thereby preventing motor deficits caused by muscle atrophy and reducing dopaminergic neuron loss (Hanscom et al., 2021)

This result laid the foundation for developing RNA double-stranded drugs, including microRNAs (miRNAs) and small interfering RNAs (siRNAs)

Li S, Zhu G, Yang Y, Jian Z, Guo S, Dai W, et al

doi: 10.1073/pnas.89.10.4678