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Renal insufficiency, indicated by serum creatinine levels of 1.5 mg/dL or higher in men and 1.4 mg/dL or higher in women, is a contraindication for metformin therapy

One of the most striking observations from these studies is that only a small fraction of the signalling changes seen in insulin resistance involved canonical insulin signalling proteins [3234]

Because ammonia (ammonium ion) is a neurotoxin its level in the blood must be kept relatively low, so it must be not be transported as such in the blood

Endocr Rev 26:944984 Kovacevic TB, Borkovic SS, Pavlovic SZ, Despotovic SG, Saicic ZS (2008) Glutathione as a suitable biomarker in hepatopancreas, gills and muscle of three freshwater cray fish species

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