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It is an essential component in depigmentation due to its capacity to inhibit melanin synthesis

75 Food and Agriculture Organization of the United Nations (2022)

Hypoxia-inducible factors 1 and 2 regulate trophoblast differentiation

Therefore, we can conclude that bilirubin plays a significant role in the progression of PD by accelerating dopaminergic neuron death in the substantia nigra reticulata due to excitotoxicity induced by elevated extracellular glutamate and more studies are needed to verify this conclusion

Because we assume PD is a disease directly related to the brain, the gene co-expression modules that have shown high expression in other tissues are not further investigated, although they may represent another mechanism of PD

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