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Of course, this is valid after the recommended daily dose is established, here it is referring to animals

doi: 10.1016/j.bbamcr.2018.02.010 56 ZhanMWangHXuSWYangLHChenWZhaoSXet al

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Additionally, celecoxib, a selective COX-2 inhibitor used in treating inflammation in SLE, has been shown to upregulate SR-B2 and downregulate SR-E1 in macrophagesindicating that prostaglandin pathways can modulate SR expression and potentially influence inflammatory outcomes (119)

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Mechanisms of renal apoptosis in health and disease