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Materials and Methods Animal studies Aged matched male and female C57BL/6J mice were used for the study

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doi: 10.1038/s41598-020-67939-x 35 MottaAParisDMelckD

Protein tyrosine phosphatase 1B modulates GSK3beta/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity

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81 During S-phase, oxidative DNA damage, including 8-oxoG lesions and strand breaks, activates the MRN-ATM-Chk2 cascade, halting replication to allow repair via p53/p21 activation