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Qijian Zhao for their valuable discussions and insights regarding the content of this work

doi: 10.3748/wjg.v23.i40.7242 28 HashimotoAKarimMRKuramochiMIzawaTKuwamuraMYamateJ

Mutant FUS R495X dysregulates the expression of genes associated with oxidative mitochondrial metabolism in neurons, and significantly reduces the size of mitochondria, which induces neurotoxicity (Nakaya and Maragkakis, 2018)