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doi: 10.1371/journal.pone.0231136 [DOI] [PMC free article] [PubMed] [Google Scholar] 389

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The mechanism is scientifically sound and consistently supported by animal data, but human efficacy and safety have not been established through clinical trials

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Comment: A commenter expressed concern regarding the measure's feasibility as CMS requires a minimum random sample size of 200 completed surveys and asked for clarification regarding the proposal for the minimum random sample size