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PMID: 33 HorensteinALChillemiAQuaronaVZitoAMarianiVFainiACet al

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Contraindications Noted in Published Research Because IGF-1 signaling operates through cellular proliferation pathways also implicated in oncogenic processes, the literature consistently identifies active or prior malignancy, and precancerous conditions, as contraindications for IGF-1 LR3 research use

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As a result, studies suggest calorie intake may drop by up to 39%