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5.2.4 Novel pharmacotherapies and combination treatment As a multifactorial degenerative disease, OA often responds poorly to single-target therapies ( Increasingly, ferroptosis is recognized as central to the multifaceted and dynamic pathophysiology of OA

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(2018) 62:10.1002/mnfr.201700231

Significant improvement in cardiometabolic health in healthy nonobese individuals during caloric restriction-induced weight loss and weight loss maintenance