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Rg1 significantly downregulated M1 macrophages and upregulated M2 macrophages to modulate the balance between macrophage M1/M2 polarization [254]

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This makes it a key peptide for studying metal-peptide interactions and redox-based signaling mechanisms

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Traumatic Brain Injury Support: There is ongoing research into whether Dihexa could aid in the recovery of cognitive function following injuries, though more rigorous human data is needed

If the patient declines buprenorphine or methadone therapy, then they may be treated with shorter-acting full opioid agonists to prevent withdrawal (e.g., IV morphine or oral morphine IR as needed)