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cysteine is the rate-limiting amino acid for glutathione synthesis, a decrease of cysteine will result in the low glutathione levels seen in individuals with impairment of this pathway

The starting point is data

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Loss of CCP1 or CCP5 results in pathological hyperglutamylation that precedes and drives progressive structural disorganization of the outer segment, characterized by destabilization of the distal axoneme, loss of the bulge region required for disc formation, and severe impairment of IFT

On the other hand, individuals recovering from an illness, managing chronic conditions, or addressing significant nutritional deficiencies may benefit from more frequent treatments initially, potentially several times per week, before gradually decreasing sessions as their health improves