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In addition, for GFI1B patients, bone marrow MKs showed extensive peripheral cytoplasm with irregular proplatelets and were largely devoid of cell organelles,12 while more recent in vitro differentiation assays with mutant GFI1B constructs in stem cells showed abnormal proplatelet formation.40 Further studies are needed to discover if GATA1-GFI1B co-transcriptional complexes could regulate NBEAL2 expression during megakaryopoiesis

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These include Lactobacillus rhamnosus GG, Lacticaseibacillus casei , Bifidobacterium longum , as well as next-generation taxa such as Akkermansia muciniphila and Faecalibacterium prausnitzii

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Oral administration of liposome-embedded SOD (L-SOD) could ameliorate oxidative damage and inflammatory responses via inhibition of myeloperoxidase (MPO) and pro-inflammatory cytokines, as well as protect gut barrier function by promoting the expression of the tight junction proteins occludin and zonula occluden (ZO)-1 in the colon 750