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doi: 10.1176/appi.ajp.2015.15020152 74 KimY.YeomM.TaeJ.RhimH.ChooH

Critical iron-regulatory genes that are upregulated by HIF-1, including FTH, TFR1 and DMT1, highlight the intrinsic relationship between iron metabolism and hypoxia as a fundamental aspect of cancer cell adaptation within the tumor microenvironment [88]