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Atukeren P, Yigitoglu MR (2013) The stance of antioxidants in brain tumors

Under pathological conditions, they may initially exert neuroprotective effects, yet prolonged activation often results in metabolic disturbances and neurotoxic gliotransmission, highlighting their dual role in CNS pathology and their potential in therapy [293]

Rather than abandoning the association of Hcy with CVD, revisiting the interventional approaches and interpretation of data may likely help in a better understanding of the relevance of Hcy to CVD